September 10, 2025Autophagy

KDM4A-induced tumor senescence enhances the efficacy of immunotherapy by inhibiting AGT-PHB1 axis-mediated mitophagy in colorectal cancer

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KDM4A overexpression enhances CD8+ T-lymphocyte infiltration in colorectal cancer and improves immunotherapy outcomes.
The study identified a KDM4A-AGT-PHB1 axis that mediates intracellular processes affecting tumor growth and immune response.
KDM4A linked to improved prognosis in colorectal cancer patients, emphasizing its role in tumor senescence and immune modulation.
Integrated clinical cohort analysis reveals a potential predictive system for immunotherapy responsiveness in colorectal cancer.

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KDM4A-induced tumor senescence improves immunotherapy response in colorectal cancer, suggesting a novel mechanism involving AGT and PHB1.

Cai et al. (2025) studied this question.

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