August 24, 2025Aging CellOpen Access

KDM4 Orchestrates Epigenomic Remodeling of Senescent Cells and Potentiates the Senescence‐Associated Secretory Phenotype

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Selective targeting of kdm4 reduces the senescence-associated secretory phenotype (SASP) in stromal cells, enhancing treatment efficacy.
Upregulated kdm4 correlates with poor survival in prostate cancer patients after chemotherapy, and lower methylation modifies cell behavior.
Assay for transposase-accessible chromatin combined with RNA sequencing reveals chromatin reprogramming during cellular senescence.
KDM4 presents a new therapeutic strategy to manage age-related conditions, including cancer, through its role in chromatin dynamics.

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KDM4 modulates the senescence-associated secretory phenotype in senescent stromal cells, suggesting therapeutic potential for cancer.

Zhang et al. (2025) studied this question.

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