Altered Nasal Microbiota-Metabolome Interactions in Allergic Rhinitis: Implications for Inflammatory Dysregulation

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Discussion

Observational analysis highlights altered microbiota and metabolites in allergic rhinitis patients, suggesting inflammatory links.

Distinct shifts in microbial communities were found in allergic rhinitis patients, indicating potential inflammatory links.
In total, 528 metabolites were identified, with notable changes in linoleic acid and arachidonic acid metabolism.
16S rDNA sequencing and untargeted metabolomics were utilized to explore the microbiota and metabolite association.
These findings indicate that nasal microbiota-metabolite interactions could contribute to the pathogenesis of allergic rhinitis.

Ma et al. (2025) studied this question.

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