September 10, 2025Open Access

Selective changes in cortical cholinergic signaling during learning

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Cholinergic signaling showed selective plasticity in cortical subnetworks during visual learning.
Simultaneous dual-color imaging revealed dynamic changes in ACh and calcium signaling across learning stages.
A novel transformer model identified key cortical regions that reorganize with learning, enhancing task performance.
Findings highlight the role of acetylcholine in learning-related plasticity within the neocortex.

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Simultaneous imaging reveals cholinergic signaling plasticity in cortical areas during learning, suggesting new roles for acetylcholine.

Ortega et al. (2025) studied this question.

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