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September 10, 2025Frontiers in ImmunologyOpen Access

Integrative transcriptomic and machine learning analyses identify HDAC9 as a key regulator of mitochondrial dysfunction and senescence-associated inflammation in diabetic nephropathy

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Authors

JHJing HuangDPDong PangCFChun‐Po Steve Fan

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Overview

Integrative analysis identifies HDAC9's role in mitochondrial dysfunction and senescence in diabetic nephropathy, suggesting therapeutic potential.

Key Points

  • HDAC9 plays a crucial role in mitochondrial dysfunction and senescence-associated inflammation in diabetic nephropathy.
  • A total of 2,176 differentially expressed genes were identified, with 259 being mitochondrial-related and 273 related to senescence.
  • Integrative machine learning revealed five hub genes, with HDAC9 highlighted due to its high diagnostic accuracy and functional relevance.
  • Functional studies show that HDAC9 knockdown reduces mitochondrial impairment and inflammation in diabetic nephropathy models.

Cite This Study

Huang et al. (2025) studied this question.

synapsesocial.com/papers/68c243f6b210217d647a8d9bhttps://doi.org/10.3389/fimmu.2025.1627173
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