September 10, 2025Advanced ScienceOpen Access

Human Brain Cell‐Type‐Specific Aging Clocks Based on Single‐Nuclei Transcriptomics

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Cell-type-specific aging clocks accurately predict chronological age in brain cells, revealing distinct aging processes.
Transcriptomic changes include increased inflammatory response genes in microglia from older brains, linked to aging.
Analysis utilized single-nucleus RNA sequencing data from 31 human donors, aged 18-94, ensuring comprehensive insights.
Findings imply potential mechanisms of selective vulnerability in Alzheimer's disease and schizophrenia, warranting further exploration.

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Observational analysis identifies unique aging trajectories in brain cells, indicating implications for neurodegenerative diseases.

Muralidharan et al. (2025) studied this question.

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