September 23, 2025Open Access

A single-cell transcriptome atlas of cell diversity in human prefrontal cortex across the postnatal lifespan

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Significant changes in brain transcriptomes occur during the 30s and 50s, impacting neurodegenerative risks.
Aging leads to downregulated synaptic functions and inflammatory responses, particularly in astrocytes and microglia.
Over 587,000 nuclei data from individuals aged 19–101 were integrated to construct a comprehensive aging atlas.
The study highlights potential biomarkers like FUT9, suggesting pathways for targeted interventions in brain aging.

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Analysis reveals brain aging impacts synaptic development and modifies astrocytes and microglia in the prefrontal cortex.

Niu et al. (2025) studied this question.

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