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September 10, 2025Acta DiabetologicaOpen Access

Serum uric acid to HDL-Chol ratio (UHR) is associated with insulin resistance/sensitivity in individuals without diabetes

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Authors

MRMariangela RubinoMMMattia MassiminoEMElettra Mancuso

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Overview

This research investigates the link between uric acid to HDL cholesterol ratio and insulin resistance, suggesting UHR may serve as a metabolic risk marker.

Key Points

  • Uric acid to HDL cholesterol ratio (UHR) shows strong correlations with insulin resistance indicators.
  • In two independent cohorts, UHR positively correlates with HbA1c, fasting insulin, and triglycerides.
  • The study highlights statistical significance in the association of UHR with metabolic risk factors.
  • UHR's easy derivation from routine measurements suggests its potential in early diabetes prevention strategies.

Cite This Study

Rubino et al. (2025) studied this question.

synapsesocial.com/papers/68c24364b210217d647a66c7https://doi.org/10.1007/s00592-025-02576-2
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A STUDY ON SIGNIFICANCE OF URIC ACID TO HDL CHOLESTEROL RATIO TO ASSESS THE CARDIOVASCULAR RISK IN TYPE 2 DIABETES MELLITUS2025
  2. 2Unveiling the UHR threshold in American adult: a new biomarker for early diabetes detection from NHANES study2025 · 2 citations
  3. 3MHR Was Associated with Hyperuricemia Risk in Patients with Type 2 Diabetes Mellitus: The Mediating Effect of Body Mass Index2025 · 3 citations
  4. 4A Cross-Sectional Study of the Association Between Uric Acid-to-High-Density Lipoprotein Cholesterol Ratio and Carotid Atherosclerosis in Patients with Type 2 Diabetes Mellitus.2025
  5. 5Association Between Uric‐Acid‐to‐HDL Ratio and Hepatic Steatosis Diagnosed by Liver Ultrasound Transient Elastography2026