September 10, 2025

Development and Validation of a Novel HPTLC Method for the Simultaneous Estimation of Ticagrelor and Aspirin in Bulk and Pharmaceutical Tablet Formulations

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The developed HPTLC method effectively estimates both ticagrelor and aspirin in pharmaceutical tablets.
Calibration plots demonstrated linearity for ticagrelor (360–1080 ng/spot) and aspirin (300–900 ng/spot) with high correlation coefficients over 0.9994.
Chromatographic separation utilized a mobile phase of cyclohexane, ethyl acetate, and glacial acetic acid, enabling reliable detection.
Validation confirmed the method's accuracy, precision, robustness, and specificity, essential for quality control in pharmaceuticals.

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Validated HPTLC method assesses ticagrelor and aspirin in tablets, highlighting accuracy and efficiency.

Bhusari et al. (2025) studied this question.

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