September 10, 2025Odesa National University Herald ChemistryOpen Access

VALIDATION OF HPLC METHOD FOR COMPARATIVE STABILITY DETERMINATION IN STUDYING THE DELIVERY OF THE DRUG TICAGRELOR VIA NASOGASTRIC TUBE (in vitro)

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HPLC method validation demonstrated high regression linearity (0.99999) for analyzing ticagrelor stability.
The method achieved satisfactory repeatability with a range of 1.68–1.84%, ensuring reliable drug delivery via nasogastric tube.
Stability of ticagrelor was continuously assessed, adhering to ICH Q3B guidelines for related substances.
Comprehensive criteria for method validation included specificity, accuracy, and robustness without needing complex reagents.

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Implication

This research validates an HPLC method for stability and impurity assessment of ticagrelor, indicating its effectiveness in drug delivery via nasogastric tube.

Cite This Study

Yegorova et al. (2025) studied this question.

synapsesocial.com/papers/68c23bd7b210217d64786f0b https://doi.org/10.18524/2304-0947.2025.1(89).335200

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Implication

This research validates an HPLC method for stability and impurity assessment of ticagrelor, indicating its effectiveness in drug delivery via nasogastric tube.

VALIDATION OF HPLC METHOD FOR COMPARATIVE STABILITY DETERMINATION IN STUDYING THE DELIVERY OF THE DRUG TICAGRELOR VIA NASOGASTRIC TUBE (in vitro)

Key Points

Discussion

Implication

Cite This Study

VALIDATION OF HPLC METHOD FOR COMPARATIVE STABILITY DETERMINATION IN STUDYING THE DELIVERY OF THE DRUG TICAGRELOR VIA NASOGASTRIC TUBE (in vitro)

Key Points

Discussion

Implication

Cite This Study

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