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September 10, 2025BMC MedicineOpen Access

The causal effects of remnant cholesterol on increased risk of cardiovascular diseases in East Asians

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Authors

CLChenhao LinHWHaibo WenMYMengyao Yu

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Overview

Observational analysis reveals remnant cholesterol's linkage to cardiovascular diseases in East Asians, suggesting ethnicity-specific CVD risk factors.

Key Points

  • Genetically predicted higher remnant cholesterol levels significantly increase the risk of aortic aneurysm and ischemic heart diseases.
  • Genome-wide association studies in 14,939 Chinese individuals identified seven loci associated with circulating remnant cholesterol levels.
  • The two-sample Mendelian randomization analysis confirmed that higher remnant cholesterol is an independent risk factor for cardiovascular diseases.
  • Findings highlight the need for tailored prevention strategies due to population-specific differences in cardiovascular risk profiles.

Cite This Study

Lin et al. (2025) studied this question.

synapsesocial.com/papers/68c24317b210217d647a5cb9https://doi.org/10.1186/s12916-025-04329-y
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Variations in remnant cholesterol and the risk of cardiovascular disease: a national longitudinal cohort study2025
  2. 2Association between remnant cholesterol and atherosclerosis plaques in single and multiple vascular territories.2025
  3. 3Risk of remnant cholesterol and chronic obstructive pulmonary disease: a mendelian randomization study2025 · 2 citations
  4. 4Impact of remnant cholesterol on short-term mortality in acute decompensated heart failure: cohort study evidence from Jiangxi, China2025
  5. 5Impact of remnant cholesterol on arterial stiffness and mediating role of systolic blood pressure in chinese hypertensive adults2025