Sporothrix brasiliensis Treatment Failure without Initial Elevated Itraconazole MICs in Felids at Border of Brazil

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Observational analysis revealed high treatment failure in cats with sporotrichosis, suggesting itraconazole may not be effective despite low MICs.

Sporotrichosis in felines shows treatment failure without high itraconazole MICs.
Elevated itraconazole MICs were not found in strains during the study involving 108 felines.
Antifungal susceptibility testing identified lower MICs for antifungal agents in yeast phases than in mycelial phases, with variations in response.
The study highlights significant mortality rates from sporotrichosis, not linked to elevated itraconazole MICs.

Prado et al. (2025) studied this question.

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Observational analysis revealed high treatment failure in cats with sporotrichosis, suggesting itraconazole may not be effective despite low MICs.