August 20, 2025Medical Mycology

In vitro susceptibility profile of Brazilian Sporothrix brasiliensis isolates to amorolfine hydrochloride and itraconazole

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Authors

LMLuciéle Pereira de MeloUniversidade Federal de Pelotas CBCaroline Quintana BragaUniversidade Federal de Pelotas CBCarolina dos Santos BermannUniversidade Federal de Pelotas

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Evaluation of amorolfine hydrochloride effectiveness against itraconazole-resistant sporotrichosis in Brazil, highlighting ongoing treatment challenges.

Key Points

Amorolfine hydrochloride demonstrated fungicidal activity in 76% of Brazilian isolates, indicating promising efficacy against sporotrichosis.
All studied isolates were susceptible to itraconazole, reinforcing its role as a first-line treatment despite reports of resistance.
Assessment of 25 Brazilian sporothrix brasiliensis isolates was conducted to determine their in vitro susceptibility to both treatments.
Findings emphasize the need for ongoing surveillance of antifungal resistance in endemic regions of Brazil to inform therapy choices.

Cite This Study

Melo et al. (2025) studied this question.

synapsesocial.com/papers/68af76bf7567bf4f94feff7f https://doi.org/10.1093/mmy/myaf075

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Implication

Evaluation of amorolfine hydrochloride effectiveness against itraconazole-resistant sporotrichosis in Brazil, highlighting ongoing treatment challenges.

In vitro susceptibility profile of Brazilian Sporothrix brasiliensis isolates to amorolfine hydrochloride and itraconazole

Discussion

Member takes

Implication

Key Points

Cite This Study

In vitro susceptibility profile of Brazilian Sporothrix brasiliensis isolates to amorolfine hydrochloride and itraconazole

Discussion

Member takes

Implication

Key Points

Cite This Study

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