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September 10, 2025Journal of Experimental & Clinical Cancer ResearchOpen Access

TRP channels and cancer modulation: a voyage beyond metabolic reprogramming, oxidative stress and the advent of nanotechnologies in targeted therapy

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Authors

MGMarialaura GiannaccariCFChiara FlorindiNBNora Bloise

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Overview

This review examines TRP channels' involvement in cancer metabolism and oxidative stress, suggesting new pathways for targeted therapy.

Key Points

  • TRP channels play a vital role in cancer progression by influencing oxidative stress levels.
  • Dysregulated TRP channels can lead to metabolic reprogramming, favoring glycolysis over oxidative phosphorylation.
  • Nanotechnology enables targeted modulation of TRP channels, enhancing anticancer treatment strategies.
  • This review integrates molecular insights with technological advancements to propose innovative cancer therapies.

Cite This Study

Giannaccari et al. (2025) studied this question.

synapsesocial.com/papers/68c2427db210217d647a42echttps://doi.org/10.1186/s13046-025-03495-4
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  4. 4Functional Aspects of TRPC Channels in Physiology and Clinical Practice: a Systematic Review2025
  5. 5Molecular Mediators of Metabolic Reprogramming in Cancer: Mechanisms, Regulatory Networks, and Therapeutic Strategies2025