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September 10, 2025BMC Pulmonary MedicineOpen Access

Efficacy and safety of inhaled ambroxol solution in improving sputum of lower respiratory tract infection in children: a multicenter, randomized, double-blind, placebo-controlled trial

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Authors

BXBaoping XuPHPeng HanYSYunxiao Shang

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Overview

Randomized, double-blind trial shows inhaled ambroxol reduces sputum in children with LRTIs, indicating it is a safe treatment.

Key Points

  • Inhaled ambroxol significantly reduces sputum symptoms in children with LRTIs compared to placebo.
  • Cough score differences between ambroxol and placebo were statistically significant (P < 0.05) after treatment.
  • The trial involved 236 children, receiving ambroxol or placebo twice daily for 7 days in a double-blind design.
  • Ambroxol showed lower adverse events compared to placebo (21.37% vs. 35.59%, P = 0.021), suggesting safety.

Cite This Study

Xu et al. (2025) studied this question.

synapsesocial.com/papers/68c24236b210217d647a2eb0https://doi.org/10.1186/s12890-025-03845-0
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