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August 17, 2025Asia Pacific AllergyOpen Access

Efficacy and safety of xyloglucan nasal spray in children with allergic rhinitis: A randomized, double-blind, placebo-controlled, crossover study

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Authors

PLPiyapong LaopakornPKPotjanee KiewngamWJWanlapa Jotikasthira

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Overview

Randomized controlled trial shows xyloglucan nasal spray improves nasal congestion in children with allergic rhinitis, suggesting it may be an effective adjunct treatment.

Key Points

  • Xyloglucan nasal spray significantly reduced nasal congestion compared to placebo in children with allergic rhinitis.
  • A reduction in visual analog scale scores by β = −1.013 (P = 0.006) indicates promising efficacy.
  • This randomized, double-blind, placebo-controlled crossover study involved 79 children aged 6-18 years with allergic rhinitis.
  • Xyloglucan treatment displayed mild adverse events, indicating it was well tolerated compared to placebo.

Cite This Study

Laopakorn et al. (2025) studied this question.

synapsesocial.com/papers/68a35152234c60ad5c20d1bdhttps://doi.org/10.5415/apallergy.0000000000000221
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