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September 10, 2025PathogensOpen Access

Extracellular Vesicle Release from Immune Cells in Cutaneous Leishmaniasis: Modulation by Leishmania (V.) braziliensis and Reversal by Antimonial Therapy

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Authors

VCVanessa CostaTCThaize Quiroga ChometonKCKatherine Kelda Gomes de Castro

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Overview

This study reveals how Leishmania alters immune cell-derived extracellular vesicles in cutaneous leishmaniasis, suggesting potential biomarkers for monitoring treatment.

Key Points

  • Extracellular vesicle release from immune cells is altered by Leishmania (V.) braziliensis, impacting disease progression.
  • In CD4+ and CD14+ cells, extracellular vesicle concentrations significantly decreased before treatment, with recovery noted during treatment.
  • Using a modified lymphocyte proliferation assay and nano-flow cytometry, immune cell-derived vesicles were analyzed from CL patients across clinical stages.
  • The findings underscore the potential of extracellular vesicles as biomarkers for assessing disease activity and therapeutic effects.

Cite This Study

Costa et al. (2025) studied this question.

synapsesocial.com/papers/68c241efb210217d647a145dhttps://doi.org/10.3390/pathogens14080771
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Unleashing the immune modulatory potential of Leishmania amazonensis-derived extracellular vesicles in American cutaneous leishmaniasis2025 · 1 citations
  2. 2mGem: Extracellular vesicles in Leishmania —secret messengers driving infection and disease2025 · 1 citations
  3. 3Protein dysregulation during Leishmania infantum infection in anti-TNF immunosuppressed mice revealed through quantitative proteomics analysis of extracellular vesicles2025 · 1 citations
  4. 4Proteomics of plasma-derived extracellular vesicles from human patients identifies biomarkers for monitoring visceral leishmaniasis therapy2025 · 2 citations
  5. 5Systematic suppression of Leishmania (Leishmania) amazonensis-mediated delayed-type hypersensitivity response in American cutaneous leishmaniasis2025 · 1 citations