September 10, 2025Frontiers in ImmunologyOpen Access

Protein dysregulation during Leishmania infantum infection in anti-TNF immunosuppressed mice revealed through quantitative proteomics analysis of extracellular vesicles

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Discussion

Analysis shows dysregulated proteins in visceral leishmaniasis during anti-TNF immunosuppression, suggesting treatment implications.

A total of 223 dysregulated proteins were identified prior to treatment, notably downregulated under anti-TNF conditions.
In the Sb-treatment groups, 173 proteins were enriched in samples treated with anti-TNF and Sb, indicating altered protein responses.
Extracellular vesicles were analyzed using quantitative proteomics to explore their role in VL severity and treatment outcomes.
These findings may inform improved clinical strategies for managing visceral leishmaniasis in immunosuppressed patients.

Bernardo et al. (2025) studied this question.

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