September 10, 2025Annals of Surgical OncologyOpen Access

Identification of Patients at Elevated Cancer Risk through a Community-Based Genetic Testing Program

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A total of 14,192 women were screened for hereditary cancers, and 23% met NCCN criteria for testing.
Of the women who opted for genetic testing, 7.6% were found to have pathogenic variants, indicating an increased cancer risk.
The community-based program identified individuals at risk for various cancers including breast, colon, and ovarian.
5.3% of the tested population qualified for MRI or earlier mammograms, suggesting enhanced screening strategies.

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Retrospective review shows 7.6% of women had pathogenic variants in hereditary cancer genes, indicating need for enhanced screening.

Brabender et al. (2025) studied this question.

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