August 1, 2025JCO Precision Oncology

Comprehensive Screening for Early Cancer Detection in Individuals With Genetic Predisposition

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The screening program identified 10.2% of healthy P/LP variant carriers with cancer, indicating effective early detection strategies.
Most early-stage cancers (96.4%) were diagnosed at stages I to II among carriers, suggesting timely interventions are possible.
Participants included 816 individuals with confirmed germline P/LP variants, assessed through clinical and laboratory monitoring.
Important findings point to aggressive breast cancer subtypes being identified at early stages, highlighting the need for tailored screening approaches.

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Implication

This program demonstrates increased early cancer detection rates in individuals with genetic predisposition, emphasizing the importance of targeted screening strategies.

Cite This Study

Бодунова et al. (2025) studied this question.

synapsesocial.com/papers/68af3e49cf1dd9ea359eb643 https://doi.org/10.1200/po-25-00333

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Implication

This program demonstrates increased early cancer detection rates in individuals with genetic predisposition, emphasizing the importance of targeted screening strategies.

Comprehensive Screening for Early Cancer Detection in Individuals With Genetic Predisposition

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Discussion

Implication

Cite This Study

Comprehensive Screening for Early Cancer Detection in Individuals With Genetic Predisposition

Key Points

Discussion

Implication

Cite This Study

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