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September 10, 2025International Journal of Allied Medical Sciences and Clinical Research

Formulation Development and In-Vitro Characterization of Liquid and Solid Self Microemulsifying Drug Delivery System of Apremilast

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Authors

UDUmamaheswari Umamaheswari DSRSatish Babu RajulapatiSMSheik Abdulla Kapoor. M

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Overview

This research reports enhanced dissolution rates for Apremilast using self-microemulsifying systems, indicating improved bioavailability.

Key Points

  • Solid self-microemulsifying drug delivery systems significantly enhance the dissolution rate of apremilast.
  • The study showed that enhanced bioavailability occurred through the formation of microemulsions upon dilution in gastric fluids.
  • Both liquid and solid formulations were characterized using in-vitro techniques including SEM, DSC, and XRD.
  • Results indicate that solid SMEDDS can improve solubility and therapeutic efficacy for poorly soluble drugs.

Cite This Study

D et al. (2025) studied this question.

synapsesocial.com/papers/68c2416eb210217d6479ea7bhttps://doi.org/10.61096/ijamscr.v13.iss2.2025.259-279
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Advancements and Innovations in Herbal and non-herbal, Self-Micro emulsifying Drug Delivery Systems (SMEDDS): A Comprehensive Review2025
  2. 2Development of Mesalamine Self Nanoemulsifying Drug Delivery System to Improve Solubility and Permeability2025
  3. 3Revolutionizing Drug Delivery: The Promise of Self-emulsifying Systems in Overcoming Bioavailability Challenges2025
  4. 4Advances in Self-Nanoemulsifying Drug Delivery Systems: Mechanistic Insights and Formulation Strategies2025
  5. 5Formulation and Evaluation of Self Micro Emulsifying Drug Delivery System of Haloperidol2025