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September 10, 2025Frontiers in PediatricsOpen Access

The clinical value of immune cell composition in the diagnosis of pediatric sepsis

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Authors

JSJie ShenQZQing ZhongYWYuqiang Wang

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Overview

Retrospective study shows that immune cell ratios improve diagnostic performance in pediatric sepsis, indicating significant clinical value.

Key Points

  • Elevated immune markers in children with sepsis indicate potential for enhanced diagnostics.
  • The NLR and PLR ratios demonstrate strong predictive value with AUCs of 0.932 and 0.907, respectively.
  • ROC analysis identified effective immune cell ratios, highlighting their role in sepsis diagnosis.
  • Combining immune ratios and CRP improves early detection, offering better outcomes for pediatric patients.

Cite This Study

Shen et al. (2025) studied this question.

synapsesocial.com/papers/68c24126b210217d6479e4fchttps://doi.org/10.3389/fped.2025.1599694
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Also Consider

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  1. 1Combination of nucleated red blood cells and inflammatory biomarkers (PCT and CRP) for predicting sepsis and septic shock in children.2025
  2. 2Strengthening the Capacity of Healthcare Providers through the Introduction of Hematological Indices as Sepsis Markers2025
  3. 3[Application value of pediatric sepsis-induced coagulopathy score and mean platelet volume/platelet count ratio in children with sepsis].2025
  4. 4The Diagnostic and Prognostic Value of Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios in Urosepsis2025 · 1 citations
  5. 5TO STUDY THE USE OF NEUTROPHIL-TO-LYMPHOCYTE RATIO AS AN EARLY MARKER OF SEPSIS IN NEONATES IN A TERTIARY CARE HOSPITAL2025