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September 10, 2025

Combination of nucleated red blood cells and inflammatory biomarkers (PCT and CRP) for predicting sepsis and septic shock in children.

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Authors

KPKaibin PuChildren's Hospital of Chongqing Medical UniversityCWChunyi WangGeorgia Institute of TechnologyJCJie ChengNantong University

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Implication

Observational analysis identified nucleated red blood cell count, CRP, and PCT as significant predictors in children, implying improved diagnostic accuracy.

Key Points

  • The combination of nucleated red blood cells, CRP, and PCT significantly predicts septic shock in children.
  • ROC analysis showed an AUC of 0.956 for the biomarker combination, indicating high predictive accuracy.
  • Children with septic shock had poorer clinical outcomes, with 63.4% experiencing disease progression or death.
  • Significant laboratory differences were found between sepsis and septic shock patients, highlighting severity indicators.

Cite This Study

Pu et al. (2025) studied this question.

synapsesocial.com/papers/68c23b8fb210217d647854edhttps://doi.org/10.3389/fcimb.2025.1603216
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