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September 10, 2025Frontiers in ImmunologyOpen Access

Harnessing innate immunity against glioblastoma microenvironment

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Authors

WZWenbo ZhangWZWanhong ZhangHWHenghao Wu

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Overview

This review explores innate immunity's role in glioblastoma, emphasizing strategies to enhance immunotherapy efficacy through innate immune modulation.

Key Points

  • Therapeutic strategies addressing innate immunity can significantly reshape glioblastoma's immunosuppressive microenvironment.
  • Innate immune cells like tumor-associated macrophages and myeloid-derived suppressor cells promote glioblastoma progression.
  • Cytokine secretion from innate immune cells inhibits effective T-cell responses, presenting challenges for existing immunotherapy.
  • Integrating innate immune modulation with immunotherapies can help overcome therapeutic resistance in glioblastoma patients.

Cite This Study

Zhang et al. (2025) studied this question.

synapsesocial.com/papers/68c240deb210217d6479c45dhttps://doi.org/10.3389/fimmu.2025.1648601
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Immunosuppressive Microenvironment of Glioblastoma: Mechanisms, Clinical Challenges, and Future Directions2025
  2. 2Enhancing T Cell Infiltration in Glioblastoma: A Review Article on Challenges and Therapeutic Strategies2025
  3. 3Immunopathology of Glioblastoma2025
  4. 4EP08.01 THE IMMUNE LANDSCAPE OF BRAIN TUMORS: IMPLICATIONS FOR NEUROIMMUNOLOGY AND NEURO-ONCOLOGY THERAPIES2025
  5. 5Harnessing the innate immune system for glioblastoma therapeutics2025