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September 10, 2025CureusOpen Access

Statin-Associated Necrotizing Autoimmune Myopathy: Unmasking 3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR) Antibody-Positive Disease After Statin Re-exposure

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Authors

ACAurora CafuliAMAntônio Camargo MartinsNONosagie Ohonba

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Overview

A case reveals worsening muscle weakness and elevated creatine kinase post-statin therapy, indicating potential risk for NAM.

Key Points

  • Worsening muscle weakness and elevated creatine kinase levels were observed after statin therapy resumption.
  • The case highlighted the role of HMGCR antibodies in diagnosing necrotizing autoimmune myopathy (NAM).
  • Diagnostic imaging and muscle biopsy confirmed inflammatory myopathy in the patient with a history of statin use.
  • Clinicians are urged to consider NAM in patients with unexplained muscle symptoms while on statins.

Cite This Study

Cafuli et al. (2025) studied this question.

synapsesocial.com/papers/68c23fc3b210217d647985b2https://doi.org/10.7759/cureus.89275
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Statin-related immune-mediated necrotizing myopathy: a case report2026
  2. 2Statin-Associated Immune-Mediated Necrotizing Myopathy: A Case Report2025
  3. 3Clinical Characteristics and Management of Statin-Associated Anti-3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase Immune-Mediated Necrotizing Myopathy2025 · 2 citations
  4. 4Therapeutic Uncertainty in Statin-Induced Necrotizing Autoimmune Myopathy: A Case Highlighting Limited Recovery Despite Aggressive Treatment (P8-9.021)2026
  5. 5Drug-induced myopathy with acute kidney injury (A case report)2025