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September 10, 2025Stem Cell Research & TherapyOpen Access

hUC-MSCs and derived exosomes attenuate DEX-induced muscle atrophy through modulation of estrogen signaling pathway

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Authors

NLNa LiXLXiaoqin LiuQWQiong Wang

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Overview

Preclinical research shows hUC-MSCs and exosomes improve muscle health in mice, suggesting a strategy for sarcopenia management.

Key Points

  • hUC-MSCs and MSC-Exos significantly improved grip strength and muscle structure in mice with dexamethasone-induced atrophy.
  • The treatment led to enhanced muscle fiber area and increased estrogen signaling, while reducing markers of inflammation and muscle atrophy.
  • Mechanistic analysis revealed activation of PI3K/AKT/mTOR and ERK1/2 signaling pathways as key contributors to muscle protection.
  • MSC-Exos demonstrated superior effects compared to hUC-MSCs in promoting myotube proliferation and differentiation.

Cite This Study

Li et al. (2025) studied this question.

synapsesocial.com/papers/68c23fc3b210217d64797e87https://doi.org/10.1186/s13287-025-04328-z
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