Treatment with UCMSC-derived exosomes enhances osteogenic differentiation and autophagy in jaw bone marrow stem cells, suggesting therapeutic potential for aging.
Key Points
UCMSC-derived exosomes significantly rejuvenated senescent jaw bone marrow stem cells, improving their osteogenic differentiation.
The treatment led to notable decreases in cellular senescence markers, with reductions in pro-inflammatory cytokines like IL-6 and TNF-α.
Analyses revealed that UCMSC-Exos restored autophagy pathways by modulating the PI3K/AKT/mTOR signaling pathway in treated cells.
In vivo results demonstrated that UCMSC-Exos enhanced bone repair capabilities in aged rat models with calvarial defects.