October 12, 2025Molecular OncologyOpen Access

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

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Authors

GCGiovanna Maria Stanfoca Casagrande MSMarcela de Oliveira Silva RRRui Manuel Reis

Discussion

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Overview

Observational analysis demonstrates actionable mutations in non-small-cell lung cancer, indicating potential for early detection and disease surveillance.

Key Points

Liquid biopsies identified key mutations in circulating tumor DNA from Brazilian lung cancer patients, enabling precise treatment strategies.
CTDNA analysis detected non-small-cell lung cancer mutations such as TP53 and EGFR, highlighting their frequency in patient samples.
Evaluation utilized the Oncomine Lung cfDNA Assay with significant median read coverage of 80,967 for variant detection.
Findings suggest the utility of an NGS panel for disease surveillance, with implications for monitoring and early diagnosis of lung cancer.

Cite This Study

Casagrande et al. (2025) studied this question.

synapsesocial.com/papers/68ebe3d6becc64ad52fdaf5d https://doi.org/10.1002/1878-0261.70131

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October 12, 2025Molecular OncologyOpen Access

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

View Full Paper

Ask AI

Bookmark

Authors

GCGiovanna Maria Stanfoca Casagrande MSMarcela de Oliveira Silva RRRui Manuel Reis

Discussion

Member takes

Overview

Observational analysis demonstrates actionable mutations in non-small-cell lung cancer, indicating potential for early detection and disease surveillance.

Key Points

Liquid biopsies identified key mutations in circulating tumor DNA from Brazilian lung cancer patients, enabling precise treatment strategies.
CTDNA analysis detected non-small-cell lung cancer mutations such as TP53 and EGFR, highlighting their frequency in patient samples.
Evaluation utilized the Oncomine Lung cfDNA Assay with significant median read coverage of 80,967 for variant detection.
Findings suggest the utility of an NGS panel for disease surveillance, with implications for monitoring and early diagnosis of lung cancer.

Cite This Study

Casagrande et al. (2025) studied this question.

synapsesocial.com/papers/68ebe3d6becc64ad52fdaf5d https://doi.org/10.1002/1878-0261.70131

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