Endothelial Tgfbr2 Deficiency Ameliorate Liver Fibrosis Through Regulating Angiocrine Signalling and Macrophage Accumulation

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Tgfbr2 deficiency reduces liver fibrosis by regulating macrophage recruitment and angiocrine signalling.
ScRNA-seq data indicates TGFBR2 levels are higher in LSECs from cirrhotic individuals compared to healthy ones.
LSEC-specific Tgfbr2 knockout showed decreased capillarisation and inflammatory responses during liver injury.
Findings suggest targeting TGFBR2 in LSECs may be an effective strategy for managing liver fibrotic diseases.

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Research reveals Tgfbr2 deletion mitigates liver fibrosis by modulating angiocrine signalling and macrophage activity.

Huang et al. (2025) studied this question.

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