TSC22D1 promotes liver sinusoidal endothelial cell dysfunction and induces macrophage M1 polarization in non-alcoholic fatty liver disease

View Full Paper

Ask AI

Bookmark

TSC22D1 promotes liver fibrosis by inducing M1 macrophage polarization in NAFLD.
Single-cell analysis highlighted TSC22D1's role linking LSECs and macrophages through the TWEAK/FN14 pathway.
In vitro studies confirmed that TSC22D1 exacerbates LSEC dysfunction and inflammatory responses in NAFLD mice.
Inhibition of TSC22D1 reduced NAFLD progression and liver fibrosis, suggesting therapeutic potential.

Discussion

No takes yet. Share an insight, caveat, or question.

Investigation shows TSC22D1 modulates LSEC dysfunction and M1 macrophage polarization in NAFLD, indicating potential therapeutic target.

Ding et al. (2025) studied this question.

View Full Paper

Ask AI

Bookmark