September 10, 2025ChemistrySelect

Microwave‐Assisted Synthesis of New Molecular Hybrids of Benzoimidazole Containing Thiazolidine‐2,4‐diones: Design, Theoretical, In Silico, and In Vitro Antimicrobial Studies

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Compounds 3a – 3g exhibited significant antibacterial and antifungal activity against several strains, including S. aureus.
The most potent compound, 3e, displayed exceptional antifungal efficacy against A. niger and strong antibacterial effects.
Analysis included microwave-assisted synthesis and molecular docking to evaluate binding affinities for target receptors.
These findings support the development of environmentally friendly antimicrobial agents derived from benzoimidazole and thiazolidine.

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In vitro studies show enhanced antimicrobial activity of new molecular hybrids, indicating potential therapeutic applications.

Khiratkar et al. (2025) studied this question.

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