Synthesis, molecular docking and antibacterial activity of new benzimidazole compounds derived from 3,4-diaminobenzophenone containing 1,3,4-thiadiazole ring

View Full Paper

Ask AI

Bookmark

Authors

Discussion

Antibacterial activity assessed against gram-positive and gram-negative bacteria, suggesting potential as new antibiotics.

Benzimidazole compounds showed significant antibacterial activity, especially against Staphylococcus strains.
Compounds 4(B, C, D, and E) demonstrated effective results comparable to azithromycin in vitro.
Molecular docking suggested strong interaction with DNA gyrase subunit b, indicating potential mechanisms of action.
Synthesis involved multistep reactions confirming the structural integrity through spectral analysis.

Alkayar et al. (2025) studied this question.

View Full Paper

Ask AI

Bookmark