Clinical Values of serum carcinoembryonic antigen (CEA), glycoprotein antigen (CA) 50, CA19-9, and CA72-4, and the soluble fragment of cytokeratin 19 (CYFRA21-1) in early screening and prognosis prediction of colon cancer

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Results indicated that serum tumor markers CEA, CA50, CA19-9, CA72-4, and CYFRA21-1 can significantly differentiate between colon cancer patients and healthy controls.
Expressions of tumor markers in late-stage patients were notably higher compared to those in the early stage, with a significant P-value of less than 0.05.
Postoperative tumor marker levels were lower than preoperative levels, but increased when recurrence or metastasis occurred, suggesting important prognostic implications.
Combined detection of multiple tumor markers showed a higher positive detection rate for recurrence and metastasis compared to individual markers.

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Observational analysis shows higher detection rates of colon cancer through serum markers, indicating improved prognosis assessment.

Zhang et al. (2025) studied this question.

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