Diagnostic value of carcinoembryonic antigen, cancer antigen 15-3, and cell-free DNA as blood biomarkers in early detection of canine mammary tumor

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CA15-3 was found to be a more effective serum tumor biomarker for diagnosing canine mammary tumors than CEA.
Malignant mammary tumors showed significantly higher concentrations of cfDNA compared to benign tumors and healthy controls.
A significant positive correlation exists between tumor biomarker levels and histopathological grades, enhancing diagnostic accuracy.
Combining CEA and CA15-3 improved sensitivity and specificity for the detection of tumors in dogs.

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This analysis reveals blood biomarkers' diagnostic efficacy in canine mammary tumors, suggesting integration in screening protocols.

Singh et al. (2025) studied this question.

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