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September 10, 2025European Heart Journal Supplements

Mortality & inpatient hospitalizations amongst patients with cardiac light-chain amyloidosis: results from a US administrative claims database

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Authors

JCJ CatiniCCCarson C. ChowJTJeffrey C. Thompson

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Overview

Observational analysis assessed mortality and hospitalization rates in cardiac light chain amyloidosis patients, highlighting unmet needs.

Key Points

  • 1-year mortality was 9.1% among patients with cardiac light chain amyloidosis, indicating significant health challenges.
  • Among the cardiac-only group, the 1-year mortality was lower at 7.6%, suggesting better outcomes compared to those with renal involvement.
  • Daratumumab was used in 69.7% of patients, showing a mortality rate of 7.2%, demonstrating its potential impact.
  • The findings highlight ongoing health concerns for cardiac amyloidosis patients, especially those with cardiac and renal involvement.

Cite This Study

Catini et al. (2025) studied this question.

synapsesocial.com/papers/68c23ed7b210217d64793b43https://doi.org/10.1093/eurheartjsupp/suaf083.047
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Prognostic analysis of newly diagnosed systemic light-chain amyloidosis patients treated with daratumumab2025
  2. 2Real-world outcomes of daratumumab in light-chain amyloidosis patients with advanced renal failure: A TriNetX network study.2026
  3. 3Presenting features, treatment patterns and predictors of outcomes in AL amyloidosis at a tertirary care cancer centre2025
  4. 4Cardiovascular events in patients diagnosed with light chain amyloidosis in the USA: a real-world analysis utilizing electronic health records2025
  5. 5Daratumumab-based regimens in newly diagnosed mayo 2004 stage 3b AL amyloidosis: A systematic review2025