September 10, 2025European Heart Journal Supplements

New target for chemotherapy-induced cardiac dysfunction

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DPP3 was significantly elevated in doxorubicin-treated cancer and cardiac cells, indicating a stress response.
In vivo results showed that KO-DPP3 mice had 13% less fractional shortening compared to wild-type mice, highlighting the role of DPP3.
Doxorubicin treatment led to increased cDPP3 activity over three weeks, reinforcing its potential role in cardiac dysfunction.
These findings suggest that targeting DPP3 could provide insights into preventing chemotherapy-induced cardiac issues.

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Implication

Observational analysis shows cDPP3 levels elevate in cardiac and cancer cells during doxorubicin treatment, suggesting implications for cardiac dysfunction.

Cite This Study

Nordin et al. (2025) studied this question.

synapsesocial.com/papers/68c23ed7b210217d64793a08 https://doi.org/10.1093/eurheartjsupp/suaf083.187

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Implication

Observational analysis shows cDPP3 levels elevate in cardiac and cancer cells during doxorubicin treatment, suggesting implications for cardiac dysfunction.

New target for chemotherapy-induced cardiac dysfunction

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Discussion

Implication

Cite This Study

New target for chemotherapy-induced cardiac dysfunction

Key Points

Discussion

Implication

Cite This Study

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