Abstract Fri012: Dual CXCR4/CXCR7 Modulation: TC14012 as a Novel Therapeutic Strategy Against Doxorubicin-Induced Cardiotoxicity

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TC14012 significantly improved cardiac function, enhancing ejection fraction and reducing fibrosis in mice treated with doxorubicin.
The dual modulation of CXCR4 and CXCR7 with TC14012 led to reduced inflammatory cell infiltration and improved survival rates in the studied mice.
RNA-seq analysis indicated that TC14012's cardioprotective effects are linked to enhanced AMPK signalling and metabolism in cardiac cells.
Importantly, TC14012 did not diminish doxorubicin's effectiveness against EL-4 lymphoma, suggesting a safe and effective dual-target therapy.

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Experimental analysis shows tc14012 improves cardiac function in doxorubicin-treated mice, suggesting a new therapeutic approach.

Hui et al. (2025) studied this question.

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