September 10, 2025Nature CommunicationsOpen Access

Differential impacts of social isolation and enriched environment on multi-sensory brain-wide functionality and network segregation

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Social isolation leads to reduced segregation of brain networks, particularly affecting olfactory and visual networks.
Enriched environment maintains network segregation while enhancing sensory and visual cortical functions.
Sensory stimulus-evoked BOLD fMRI and resting-state fMRI techniques provide comprehensive insights into brain functionality.
Understanding the impact of environmental factors may offer new therapeutic insights for psychiatric disorders.

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Study reveals social isolation reduces brain network segregation in mice, highlighting enriched environments' benefits.

You et al. (2025) studied this question.

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