September 10, 2025Neuroreport

MCTR1 alleviates remifentanil-induced hyperalgesia by regulating mitochondrial fission protein DRP1 in rats

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MCTR1 treatment alleviates remifentanil-induced mechanical and thermal hyperalgesia in rats.
After treatment, DRP1 and NR 2 B expression decreased significantly, suggesting a protective mechanism.
Observational behavioral tests showed effective pain relief post-remifentanil infusion at multiple time points.
MCTR1 impacts mitochondrial function, reducing ROS production and related damage in the spinal cord.

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Observational analysis shows MCTR1 reduces hyperalgesia and modulates DRP1 in rats, indicating potential therapeutic effects.

Gu et al. (2025) studied this question.

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