September 5, 2025CNS Neuroscience & TherapeuticsOpen Access

Targeting Drp1 in Cerebral Ischemia–Reperfusion Injury: Mechanisms and Therapeutic Implications

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Drp1 inhibition shows promise for reducing cerebral ischemia-reperfusion injury and improving neuronal survival.
In preclinical models, Drp1 modulation restored mitochondrial homeostasis and diminished oxidative stress effects.
The review evaluates both pharmacological and genetic strategies aimed at targeting Drp1 for therapeutic benefits.
Challenges include drug specificity and long-term safety of Drp1 modulators in clinical applications.

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Implication

This review demonstrates how Drp1 influences mitochondrial dysfunction and oxidative stress in cerebral ischemia, suggesting therapeutic interventions.

Cite This Study

Liu et al. (2025) studied this question.

synapsesocial.com/papers/68c23922b210217d6477aa6c https://doi.org/10.1111/cns.70590

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Implication

This review demonstrates how Drp1 influences mitochondrial dysfunction and oxidative stress in cerebral ischemia, suggesting therapeutic interventions.

Targeting Drp1 in Cerebral Ischemia–Reperfusion Injury: Mechanisms and Therapeutic Implications

Key Points

Discussion

Implication

Cite This Study

Targeting Drp1 in Cerebral Ischemia–Reperfusion Injury: Mechanisms and Therapeutic Implications

Key Points

Discussion

Implication

Cite This Study

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