September 10, 2025Frontiers in OncologyOpen Access

Bioinformatics-based prognostic value and in vitro functional validation of PTK6 in cutaneous melanoma

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High expression of PTK6 is linked to worse overall survival in cutaneous melanoma patients, indicating its prognostic importance.
A risk score model based on differentially expressed genes effectively differentiates high- and low-risk patients in cutaneous melanoma.
In vitro validation shows that PTK6 promotes melanoma cell proliferation, invasion, and migration, emphasizing its therapeutic potential.
Further multi-center studies are needed to fully explore the clinical implications and mechanisms of PTK6 in cutaneous melanoma.

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Bioinformatics analysis identifies PTK6 as a prognostic biomarker in cutaneous melanoma, suggesting its role in treatment response.

Niu et al. (2025) studied this question.

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