August 16, 2025Discover OncologyOpen Access

PTK6 mediated immune signatures revealed by single cell transcriptomic and multi omics big data analysis in cervical cancer

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PTK6 serves as a critical biomarker, significantly correlating with immune infiltration in cervical cancer.
The prognostic model developed achieved AUC values of 0.737-0.757, indicating excellent predictive performance.
Single-cell RNA sequencing identified distinct cellular populations, including CD8T cells, CD4Tconv cells, and fibroblasts.
Machine learning algorithms constructed prognostic models using immune infiltration-related genes, enhancing prediction accuracy.

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Single-cell RNA sequencing reveals PTK6's role in immune infiltration and its potential as a prognostic model for cervical cancer.

Zhao et al. (2025) studied this question.

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