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September 10, 2025Frontiers in Aging NeuroscienceOpen Access

Mechanistic exploration of obesity-related indicators and motor cognitive risk syndrome: a mediated effect based on C-reactive protein triglyceride glucose index

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Authors

ZGZhongqiang GuoSDShuang DengLLLi Li

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Overview

Observational study reveals obesity factors influence motor cognitive risk syndrome, indicating metabolic disorders play a mediating role.

Key Points

  • Obesity-related indicators significantly increase the risk of motor cognitive risk syndrome.
  • Mediation analysis indicates metabolic disorders mediate effects between waist to height ratio and MCR by 20.99%.
  • Multiple logistic regression and curve fitting reveal non-linear and linear relationships among obesity indicators and MCR.
  • The findings suggest the need for incorporating waist to height ratio and C-reactive protein into community health assessments.

Cite This Study

Guo et al. (2025) studied this question.

synapsesocial.com/papers/68c23e4fb210217d6479121dhttps://doi.org/10.3389/fnagi.2025.1623148
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Nonlinear association between TyG-related Indices and motoric cognitive risk syndrome in depressive individuals: evidence from the CHARLS study2025
  2. 2Comparative predictive values of anthropometric indices for cardiometabolic multimorbidity in middle-aged and older adults: a prospective study from the CHARLS study2025 · 5 citations
  3. 3Association between C-reactive protein-triglyceride glucose related indices and all-cause and cardiovascular mortality in individuals with cardiovascular-kidney-metabolic syndrome2026
  4. 4Association of C-reactive protein-triglyceride glucose index and its modified indices with stroke risk in individuals at cardiovascular-kidney-metabolic syndrome stages 0–3: a population-based cohort study2026
  5. 52229-P: Association between C-Reactive Protein–Triglyceride–Glucose Index and New-Onset Chronic Disease Incidence and Mortality: Evidence from Multinational Cohorts2026