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September 10, 2025Russian Journal of Pediatric Hematology and OncologyOpen Access

Method for assessing the effect of antitumor treatment using the leukocyte ratio index in pubertal children with Hodgkinʼs lymphoma

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Authors

EFE. M. FrantsiyantsВБВ. А. БандовкинаDDD.A. Dzhavadov

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Overview

Observational analysis finds leukocyte ratio predicts treatment outcomes in pubertal children with hodgkin lymphoma, suggesting its use as a prognostic factor.

Key Points

  • Leukocyte ratio values in children with cHL were 2.4 to 4.4 times higher than in healthy peers, indicating its potential significance.
  • Patients with advanced stages of cHL showed a 1.7-fold increase in the leukocyte ratio compared to earlier stages, revealing disease progression.
  • Decreases in the leukocyte ratio were statistically significant after chemotherapy, reflecting effective treatment outcomes for both boys and girls.
  • In refractory and progressive cases, the leukocyte ratio was 2.6 times higher in boys and 4.2 times higher in girls than normal, indicating treatment response.

Cite This Study

Frantsiyants et al. (2025) studied this question.

synapsesocial.com/papers/68c23e02b210217d6478fdc6https://doi.org/10.21682/2311-1267-2025-12-1-39-47
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Treatment of children with relapsed and refractory classical Hodgkin’s lymphoma: the experience of two centers2024
  2. 2Tumor-Specific Immune Responses and Biomarkers in pediatric High-Risk Hodgkin Lymphoma Patients2025
  3. 3The impact of chemotherapy on pituitary hormonal function in pubertal children with Hodgkin’s lymphoma2025
  4. 4Diagnostic Lymphocytosis as a Favorable Prognostic Factor in Childhood Acute Myeloblastic Leukemia2025
  5. 5The evolution of treatment for pediatric advanced stage classic Hodgkin lymphoma - a narrative literature review.2025