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September 10, 2025Redox BiologyOpen Access

Metabolic Dysfunction-Associated Steatohepatitis reduces hepatic H2S-producing enzymes altering persulfidome composition

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Authors

TSTzu Keng ShenTVThibaut VignaneEGEduardo Hideo Gilglioni

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Overview

This research shows the impact of metabolic dysfunction-associated steatohepatitis on H2S enzymes, highlighting dysregulation of persulfidation in liver disease.

Key Points

  • Impaired production of hydrogen sulfide (H2S) disrupts protective persulfidation networks in metabolic dysfunction-associated steatohepatitis.
  • The study reveals downregulation of H2S-producing enzymes in human and mouse livers with steatosis, correlating with reduced persulfidation levels.
  • Dimedone-switch mass spectrometry identified specific protein dysregulation in H2S levels across various obesity-associated liver disease stages.
  • Maintaining persulfidation on redox-sensitive proteins may offer a compensatory mechanism to restore redox balance in chronic liver disease.

Cite This Study

Shen et al. (2025) studied this question.

synapsesocial.com/papers/68c23dc5b210217d6478f72ahttps://doi.org/10.1016/j.redox.2025.103809
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