September 10, 2025American Journal of Nephrology

Inflammation-Driven Differential Response to Intravenous versus Oral Iron Supplementation in Hemodialysis Patients: A Post Hoc Analysis of the IHOPE Trial

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Patients with high baseline inflammation had lower hemoglobin levels after iron supplementation, indicating altered response.
At 24 weeks, hemoglobin levels were significantly lower in high hsCRP patients receiving intravenous iron compared to those with low hsCRP.
Oral iron supplementation maintained consistent efficacy across inflammation levels, contrasting with intravenous iron.
These findings highlight the importance of tailoring iron therapy in hemodialysis patients based on inflammatory status.

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Implication

Post hoc analysis reveals that inflammation alters responses to intravenous and oral iron supplementation in hemodialysis patients, suggesting the need for individualized therapy.

Cite This Study

Jin et al. (2025) studied this question.

synapsesocial.com/papers/68c23cf6b210217d6478c024 https://doi.org/10.1159/000548166

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Implication

Post hoc analysis reveals that inflammation alters responses to intravenous and oral iron supplementation in hemodialysis patients, suggesting the need for individualized therapy.

Inflammation-Driven Differential Response to Intravenous versus Oral Iron Supplementation in Hemodialysis Patients: A Post Hoc Analysis of the IHOPE Trial

Key Points

Discussion

Implication

Cite This Study

Inflammation-Driven Differential Response to Intravenous versus Oral Iron Supplementation in Hemodialysis Patients: A Post Hoc Analysis of the IHOPE Trial

Key Points

Discussion

Implication

Cite This Study

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