September 12, 2025Renal Replacement TherapyOpen Access

Efficacy and safety of high-dose intravenous iron in the treatment of iron-deficiency anemia in patients undergoing hemodialysis: a systematic review and meta-analysis of randomized controlled trials

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High-dose intravenous iron significantly increased transferrin saturation and ferritin levels in hemodialysis patients, without improving hemoglobin levels.
Results from five randomized controlled trials involving 2614 patients showed no significant differences in adverse cardiac events between high-dose and control groups.
Heterogeneity in responses was assessed, confirming the safety of high-dose intravenous iron in the treatment of iron-deficiency anemia.
The findings suggest that high-dose intravenous iron may be safely administered to patients on hemodialysis while monitoring for adverse events.

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Implication

Systematic review and meta-analysis reveal that high-dose intravenous iron improves ferritin and transferrin saturation but not hemoglobin levels in hemodialysis patients.

Cite This Study

Campoverde et al. (2025) studied this question.

synapsesocial.com/papers/68d41da1713b0b5dfea66c75 https://doi.org/10.1186/s41100-025-00664-1

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Implication

Systematic review and meta-analysis reveal that high-dose intravenous iron improves ferritin and transferrin saturation but not hemoglobin levels in hemodialysis patients.

Efficacy and safety of high-dose intravenous iron in the treatment of iron-deficiency anemia in patients undergoing hemodialysis: a systematic review and meta-analysis of randomized controlled trials

Key Points

Discussion

Implication

Cite This Study

Efficacy and safety of high-dose intravenous iron in the treatment of iron-deficiency anemia in patients undergoing hemodialysis: a systematic review and meta-analysis of randomized controlled trials

Key Points

Discussion

Implication

Cite This Study