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September 10, 2025Diseases of the Esophagus

Prognostic Value of Circulating Tumor Dna in the Perioperative Management of Esophageal Cancer

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Authors

MSMarisa SewellMBMatthew J. BottKGKatherine D. Gray

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Overview

Retrospective analysis shows circulating tumor DNA can identify high-risk patients in esophageal cancer, suggesting improved surgical outcomes.

Key Points

  • Circulating tumor DNA presence in esophageal cancer patients correlates with disease status and surgical outcomes.
  • In the study, 63% of patients had detectable baseline circulating tumor DNA, indicating residual disease.
  • Patients achieving circulating tumor DNA clearance post-treatment experienced improved prognostic outcomes.
  • Higher pre-treatment circulating tumor DNA levels were linked to nodal metastases, suggesting poor prognosis.

Cite This Study

Sewell et al. (2025) studied this question.

synapsesocial.com/papers/68c23cf6b210217d6478b8behttps://doi.org/10.1093/dote/doaf061.051
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Also Consider

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  1. 1Circulating tumor DNA as a marker of molecular residual disease in resected esophageal squamous cell carcinoma2025 · 4 citations
  2. 2290. OPTIMIZING ESOPHAGEAL CANCER TREATMENT: PERSONALIZED CTDNA IMPROVES RESIDUAL DISEASE DETECTION AFTER NEOADJUVANT CHEMORADIOTHERAPY AND GUIDES ADAPTIVE ADJUVANT IMMUNOTHERAPY2025 · 1 citations
  3. 3Gene‐specific ctDNA dynamics predict tumour burden and survival outcomes in ESCC: A prospective cohort study2025 · 4 citations
  4. 4Detection of Molecular Residual Disease by Circulating Tumor DNA in Early-Stage Node-Negative Rectal Cancers (CCTG CO.28) Using a Tumor-Informed Assay2025
  5. 5ctDNA detects residual disease after neoadjuvant chemoradiotherapy and guides adjuvant therapy in esophageal squamous cell carcinoma2025 · 10 citations