Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
September 19, 2025Molecular BiomedicineOpen Access

Circulating tumor DNA as a marker of molecular residual disease in resected esophageal squamous cell carcinoma

View Full Paper
Ask AI
Bookmark
Share

Authors

CFCai-Yan FangJWJing WenJWJiadi Wu

Discussion

Loading...

Member takes

Overview

This study reveals circulating tumor DNA detects residual disease in esophageal squamous cell carcinoma, indicating significant implications for patient prognosis.

Key Points

  • Postoperative ctDNA-positivity was associated with higher recurrence rates in patients with ESCC, highlighting its prognostic importance.
  • Concordance rate of mutation detection between primary tumors and preoperative plasma samples was 91.11%, emphasizing ctDNA's reliability.
  • Utilization of ctDNA alongside the TNMB staging system significantly improved prognosis distinction compared to traditional methods.
  • Patients with ctDNA-positivity had a disease-free survival hazard ratio of 4.58, suggesting a critical link to long-term outcomes.

Cite This Study

Fang et al. (2025) studied this question.

synapsesocial.com/papers/68d437fe713b0b5dfea77bb6https://doi.org/10.1186/s43556-025-00310-6
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched one closely related paper. Consider it for comparative context:

  1. 1The Measurement of Observer Agreement for Categorical Data1977 · 81,349 citations