Non-Curative Factors in Endoscopic Resection of Esophageal Squamous Cell Carcinoma Diagnosed Preoperatively as Invasion Beyond the Muscularis Mucosae

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Discussion

Retrospective analysis identifies invasion depth and marginal elevation as critical factors for metastasis in ESCC.

A significant higher incidence of SMT-like marginal elevation was found in the high-risk group at 24.5%.
The 5-year overall survival rate was 88.5% for patients with high-risk lesions compared to 95.3% for low-risk lesions.
Patients were classified into high and low-risk groups based on the depth of invasion and presence of lymphovascular invasion.
Special attention to SMT-like marginal elevation may help in assessing metastatic risks during endoscopic examinations.

Watanabe et al. (2025) studied this question.

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